Several Ultra-High-Strength (UHS) wires are produced that may be well suited to high strength wire, strands, cables and ropes used in robotics force transmission and other high-performance mono- and multifilament wire applications where high strength, low stretch and fatigue durability are important. The breadth of UHS materials processed to this condition included two binary molybdenum-rhenium alloys with between 30 and 50 wt.% rhenium and one tungsten-rhenium alloy with 26 wt.% rhenium. These three alloys are processed from a moderate strength (< 2 GPa) warm-drawn rod to bright drawn monofilament wire with extreme nanocrystalline grain refinement, high apparent fatigue durability, and ultimate strength levels exceeding 5 GPa in all cases, and in excess of 6.8 GPa in one exemplary case at monofilament diameters ranging from 7 to 100 µm.